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| | Therapy is continued for ≥İ12 weeks, however treatment duration should be individualized for each patient according to clinical response (90).
Voriconazole has not been studied in HIV-contaminated children. For HIV-infected kids with lively pulmonary TB disease, the minimal beneficial duration of antituberculous drug treatment is 6 months, however some consultants recommend up to 9 months (AIII) (191). For children with extrapulmonary illness involving the bones or joints, CNS, or miliary illness, the minimal really useful duration of therapy is 12 months (AIII) (90,192).
These suggestions assume that the organism is vulnerable to the medications, adherence to the regimen has been ensured by directly observed therapy, and the child has responded clinically and microbiologically to therapy. For HIV-contaminated children diagnosed with TB disease, anti-TB treatment should be began instantly (AIII).
A retrospective report by which caspofungin was administered to 20 children aged≤¡Ü16 years who had invasive fungal infections (seven had invasive candidiasis) but not HIV infection, the drug was efficacious and properly tolerated (25  . In a research of 10 neonates with persistent and progressive candidiasis and unknown HIV standing, caspofungin was reported to be an effective alternative therapy (294).
Micafungin has been studied in HIV-uninfected, neutropenic children in danger for invasive fungal infections.
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